期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 53, 期 10, 页码 4549-4555出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00180-09
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In an in vitro pharmacodynamic model, linezolid attenuated the activity of aztreonam and ceftazidime against Escherichia coli. Conversely, synergy was detected at 24 and 48 h when daptomycin or vancomycin was added to aztreonam and ceftazidime. We conclude that significant yet underappreciated interactions may occur between gram-positive-spectrum and gram-negative-spectrum antibacterials.
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