期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 53, 期 6, 页码 2657-2659出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01663-08
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资金
- Ministere de l'Education Nationale et de la Recherche [UPRES-EA3539,]
- European Community [LSHM-CT-2005-018705]
- INSERM
- Fonds d'Etude et de Recherche du Corps Medical des Hopitaux de Paris, Paris, France
Two clonally related Acinetobacter baumannii isolates, A1 and A2, were obtained from the same patient. Isolate A2, selected after an imipenem-containing treatment, showed reduced susceptibility to carbapenems. This resistance pattern was related to insertion of the ISAba1 element upstream of the naturally occurring bla(OXA-66) carbapenemase gene as demonstrated by sequencing, reverse transcription-PCR analysis, and inactivation of the bla(OXA-66) gene.
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