期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 54, 期 1, 页码 328-332出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00961-09
关键词
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资金
- Ministere de l'Education Nationale et de la Recherche [UPRES-EA 3539]
- Universite Paris XI, Paris, France
- European Community [DRESP2, LSHM-CT-2003-503-335, TROCAR, HEALTH-F3-2008-223031]
- INSERM
A Pseudomonas fluorescens isolate (PF-1) resistant to carbapenems was recovered during an environmental survey performed with water from the Seine River (Paris). It expressed a novel Ambler class A carbapenemase, BIC-1, sharing 68 and 59% amino acid identities with beta-lactamases SFC-1 from Serratia fonticola and the plasmid-encoded KPC-2, respectively. beta-Lactamase BIC-1 hydrolyzed penicillins, carbapenems, and cephalosporins except ceftazidime and monobactams. The bla(BIC-1) gene was chromosomally located and was also identified in two other P. fluorescens strains isolated from the Seine River 3 months later.
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