期刊
NMR IN BIOMEDICINE
卷 18, 期 7, 页码 469-472出版社
WILEY
DOI: 10.1002/nbm.983
关键词
magnetite; brain; ferritin; magnetoferritin; relaxometry
资金
- NIA NIH HHS [R01 AG2030-01A1] Funding Source: Medline
Mammalian cellular iron is stored inside the multisubunit protein ferritin. normally taking the structure of a ferrihydrite-like mineral core. It has been suggested that biogenic magnetite, which has been detected in the brain and may be related to neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, could initially form in ferritin. Indeed, as ferritin is present in the brain, the ferrihydrite core could be a precursor for biogenic magnetite formation 19 particularly in cases where the normal functioning of the ferritin protein is disrupted. In this work, NMR relaxometry was used to detect magnetite inside samples of ferritin extracted from normal and Alzheimer-diseased brains. The method was first calibrated with different fractions of horse spleen ferritin and synthetic magnetite particles. The relaxometry results suggest that the proportion of iron contained in brain ferritin in the form of well-crystallized magnetite instead of ferrihydrite must be < 1%, which is much less than that reported for 'magnetite-like' phase in recent transmission electron microscopy studies of similar samples. Consequently, the magnetization of this 'magnetite-like' phase must be very low compared with that of magnetite. Copyright (c) 2005 John Wiley & Sons, Ltd.
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