期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 52, 期 12, 页码 4486-4491出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00222-08
关键词
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资金
- anadian Institutes of Health Research
- Canadian Cystic Fibrosis Foundation (CCFF)
- CIHR-UBC TRID
- Juergen Manchot Foundation
- German Cystic Fibrosis Association
- Canada Research Chair
Pseudomonas aeruginosa offers substantial therapeutic challenges due to its high intrinsic resistance to many antibiotics and its propensity to develop mutational and/or adaptive resistance. The PA14 comprehensive mutant library was screened for mutants exhibiting either two-to eightfold increased susceptibilities (revealing genes involved in intrinsic resistance) or decreased susceptibilities (mutational resistance) to the fluoroquinolone ciprofloxacin. Thirty-five and 79 mutants with increased and decreased susceptibilities, respectively, were identified, as confirmed by broth dilution.
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