期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 52, 期 12, 页码 4466-4469出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00903-08
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资金
- Stanley Medical Research Institute
New drugs are needed for treatment of Toxoplasma gondii infections. We tested derivatives of principles found in Isatis indigotica for in vitro efficacy against T. gondii infection. Indirubin-3 '-oxime analogs showed modest micromolar activity, while tryptanthrin derivatives displayed 50% inhibitory doses in the low nanomolar range. Tryptanthrins have potential as anti-Toxoplasma infection therapeutics.
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