期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 62, 期 21, 页码 2477-2486出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-005-5085-4
关键词
Down syndrome; Alzheimer's disease; cardiac hypertrophy; calcineurin; calcipressin 1; MCIP1; DSCR1; Adapt78; RCAN1
资金
- NIA NIH HHS [AG 16256] Funding Source: Medline
The DSCR1 (Adapt78) gene(1) is transiently induced by stresses to temporarily protect cells against further potentially lethal challenges. However, chronic expression of the DSCR1 (Adapt78) gene has now been implicated in several pathological conditions including Alzheimer's disease, Down syndrome and cardiac hypertrophy. Calcipressin 1 has been shown to function through direct binding and inhibition of the serine threonine protein phosphatase Calcineurin. Pharmacological inhibition of calcineurin, by the immunosuppressive drugs cyclosporin A and FK506, affects a wide variety of diseases. It is, therefore, likely that this endogenous calcineurin inhibitor, calcipressin 1, may also play a role in a variety of human diseases.
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