期刊
NEURAL NETWORKS
卷 18, 期 9, 页码 1172-1190出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neunet.2005.08.007
关键词
entorhinal cortex; dentate gyrus; region CA3; region CA1; spatial alternation; single unit recording; theta phase precession; current source density
资金
- NIDA NIH HHS [DA 16454, R01 DA016454, R01 DA016454-03] Funding Source: Medline
- NIMH NIH HHS [R01 MH060013-06, R01 MH060013, MH 61492, R01 MH061492-04, MH 60450, R01 MH061492, P50 MH060450-049002, P50 MH060450, MH 60013] Funding Source: Medline
Behaviors ranging from delivering newspapers to waiting tables depend on remembering previous episodes to avoid incorrect repetition. Physiologically, this requires mechanisms for long-term storage and selective retrieval of episodes based on the time of occurrence, despite variable intervals and similarity of events in a familiar environment. Here, this process has been modeled based on the physiological properties of the hippocampal formation, including mechanisms for sustained activity in entorhinal cortex and theta rhythm oscillations in hippocampal subregions. The model simulates the context-sensitive firing properties of hippocampal neurons including trial-specific firing during spatial alternation and trial by trial changes in theta phase precession on a linear track. This activity is used to guide behavior, and lesions of the hippocampal network impair memory-guided behavior. The model links data at the cellular level to behavior at the systems level, describing a physiologically plausible mechanism for the brain to recall a given episode which occurred at a specific place and time. (c) 2005 Elsevier Ltd. All rights reserved.
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