期刊
VACCINE
卷 23, 期 45, 页码 5205-5211出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2005.07.002
关键词
Japanese encephalitis; vaccine development; immune correlates
资金
- Medical Research Council [G116/194] Funding Source: Medline
- MRC [G116/194] Funding Source: UKRI
The World Health Organization (WHO) is Undertaking consultations on immunological responses as parameters for evaluation and licensure of new Japanese encephalitis (JE) vaccines. Immunological markers Could be used by vaccine developers and regulatory authorities to assess vaccine efficacy in absence of clinical efficacy data. The consultation which is reported here reviewed Current data on mechanisms of protective immunity gathered from animal experimentation, clinical data from licensed vaccines and from vaccine candidates still in clinical development. Immunological assays and readouts for use in evaluation of candidate vaccines were also discussed. The consultation made a series of recommendations for specifications on immunological criteria to assess JE vaccine efficacy. More detailed recommendations will be drafted following further consultations to serve as WHO guidelines for evaluation and licensure for new JE vaccines. (c) 2005 Elsevier Ltd. All rights reserved.
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