期刊
STEM CELLS
卷 23, 期 10, 页码 1468-1478出版社
WILEY
DOI: 10.1634/stemcells.2004-0371
关键词
human embryonic stem cells; epigenesis; X-chromosome inactivation; differentiation
资金
- NIGMS NIH HHS [R01 GM053234-07S1] Funding Source: Medline
Human embryonic stem cells (hESCs) derived from human blastocysts have an apparently unlimited proliferative capacity and can differentiate into ectoderm, mesoderm, and endoderm. As such, hESC lines have enormous potential for use in cell replacement therapies. It must first be demonstrated, however, that hESCs maintain a stable karyotype and phenotype and that gene expression is appropriately regulated. To date, different hESC lines exhibit similar patterns of expression of markers associated with pluripotent cells. However, the evaluation of epigenetic status of hESC lines has only recently been initiated. One example of epigenetic gene regulation is dosage compensation of the X chromosome in mammalian females. This is achieved through an epigenetic event referred to as X-chromosome inactivation (XCI), an event initiated upon cellular differentiation. We provide the first evidence that undifferentiated hESC lines exhibit different patterns of XCI. STEM CELLS 2005;23:1468-1478.
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