期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 52, 期 9, 页码 3457-3460出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00117-08
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资金
- Ortho-McNeal Pharmaceutical
- Department of Veterans Affairs
After mice received orogastric administration of a fluoroquinolone-resistant Klebsiella pneumoniae strain, subcutaneous treatment with ciprofloxacin, levofloxacin, and moxifloxacin promoted persistent low-density colonization in 10% to 40% of the mice, whereas treatment with clindamycin consistently promoted high-density colonization. No emergence of fluoroquinolone-resistant gram-negative bacilli was detected in the mice during or after treatment with the fluoroquinolone antimicrobial agents.
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