期刊
CELL CYCLE
卷 4, 期 11, 页码 1491-1494出版社
LANDES BIOSCIENCE
DOI: 10.4161/cc.4.11.2124
关键词
cyclin-dependent kinase; knockout mice; Cdk2; Cdc2; p27; cyclin E
类别
资金
- Intramural NIH HHS Funding Source: Medline
It has been long believed that the cyclin-dependent kinase 2 (Cdk2) binds to cyclin E or cyclin A and exclusively promotes the G(1)/S phase transition and that Cdc2/cyclin B complexes play a major role in mitosis. We now provide evidence that Cdc2 binds to cyclin E ( in addition to cyclin A and B) and is able to promote the G(1)/S transition. This new concept indicates that both Cdk2 and/or Cdc2 can drive cells through G(1)/S phase in parallel. In this review we discuss the classic cell cycle model and how results from knockout mice provide new evidence that refute this model. We focus on the roles of Cdc2 and p27 in regulating the mammalian cell cycle and propose a new model for cell cycle regulation that accommodates these novel findings.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据