期刊
NEUROBIOLOGY OF LEARNING AND MEMORY
卷 84, 期 3, 页码 241-246出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nlm.2005.07.006
关键词
working memory; learning; memory; intelligence; long-term memory; mice; general learning ability; general cognitive ability
资金
- NIA NIH HHS [AG022698-01] Funding Source: Medline
Up to 50% of an individuals' performance across a wide variety of distinct cognitive tests can be accounted for by a single factor (i.e., general intelligence). Despite its ubiquity, the processes or mechanisms regulating this factor are a matter of considerable debate. Although it has been hypothesized that working memory may impact cognitive performance across various domains, tests have been inconclusive due to the difficultly in isolating working memory from its overlapping operations, such as verbal ability. We address this problem using genetically diverse mice, which exhibit a trait analogous to general intelligence. The general cognitive abilities of CD-1 mice were found to covary with individuals' working memory capacity, but not with variations in long-term retention. These results provide evidence that independent of verbal abilities, variations in working memory are associated with general cognitive abilities, and further, suggest a conservation across species of mechanisms and/or processes that regulate cognitive abilities. (c) 2005 Elsevier Inc. All rights reserved.
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