期刊
JOURNAL OF ANTIBIOTICS
卷 58, 期 11, 页码 695-703出版社
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2005.95
关键词
stemphones; imipenem potentiator; methicillin-resistant Staphylococcus aureus; MRSA; fungal metabolite; tetracyclic quinone
A fungal strain FKI-2136 identified as genus Aspergillus was found to produce potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus (MRSA). Two new compounds designated stemphones B and C were isolated along with a structurally related known compound cochlioquinone D from the fermentation broth of the producing strain by solvent extraction, silica gel column chromatography and preparative HPLC. These compounds have a common tetracyclic quinone skeleton. Stemphone C potentiated imipenem activity against the MRSA 512 told by decreasing MIC value of imipenem from 16 mu g/ml to 0.03 mu g/ml.
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