期刊
ANATOMY AND EMBRYOLOGY
卷 210, 期 4, 页码 245-263出版社
SPRINGER
DOI: 10.1007/s00429-005-0048-y
关键词
mouse atlas; stereotaxic co-ordinate; feature-based registration; anatomical morphometry; MR imaging; gene expression mapping; developing brain
资金
- NCRR NIH HHS [P41 RR013642, U54 RR021813, U24 RR021760] Funding Source: Medline
- NIBIB NIH HHS [R01 EB002172] Funding Source: Medline
A standard atlas space with stereotaxic co-ordinates for the postnatal day 0 (P0) C57BL/6J mouse brain was constructed from the average of eight individual co-registered MR image volumes. Accuracy of registration and morphometric variations in structures between subjects were analyzed statistically. We also applied this atlas coordinate system to data acquired using different imaging protocols as well as to a high-resolution histological atlas obtained from separate animals. Mapping accuracy in the atlas space was examined to determine the applicability of this atlas framework. The results show that the atlas space defined here provides a stable framework for image registration for P0 normal mouse brains. With an appropriate feature-based co-registration strategy, the probability atlas can also provide an accurate anatomical map for images acquired using invasive imaging methods. The atlas templates and the probability map of the anatomical labels are available at http://www.loni.ucla.edu/MAP/.
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