期刊
PHYTOTHERAPY RESEARCH
卷 19, 期 11, 页码 988-991出版社
JOHN WILEY & SONS LTD
DOI: 10.1002/ptr.1776
关键词
Helicobacter pylori; traditional medicine; herbal; peptic ulcer disease
资金
- NCCIH NIH HHS [R21 AT000412-02] Funding Source: Medline
The gram-negative bacterium Helicobacter pylori (HP), identified in 1982, is now recognized as the primary etiological factor associated with the development of gastritis and peptic ulcer disease. In addition, HP infections are also associated with chronic gastritis, gastric carcinoma and primary gastric B-cell lymphoma. For centuries, herbals have been used in traditional medicine to treat a wide range of ailments, including gastrointestinal (GI) disorders such as dyspepsia, gastritis and peptic ulcer disease (PUD). However, the mechanism of action by which these botanicals exert their therapeutic effects has not been completely elucidated. As part of an ongoing screening program, the study assessed the in vitro susceptibility of 15 HP strains to botanical extracts, which have a history of traditional use in the treatment of GI disorders. Methanol extracts of Myristica fragrans (seed) had a MIC of 12.5 mu g/mL; Zingiber officinale (ginger rhizome/root) and Rosmarinus officinalis (rosemary leaf) had an MIC of 25 mu g/mL. Methanol extracts of botanicals with a MIC of 50 mu g/mL included Achillea millefolium, Foeniculum vulgare (seed), Passiflora incamata (herb), Origanum majorana (herb) and a (1:1) combination of Curcuma longa (root) and ginger rhizome. Botanical extracts with a MIC of 100 mu g/mL included Carum carvi (seed), Elettaria cardamoinum (seed), Gentiana lutea (roots), Juniper communis (berry), Lavandula angustifolia (flowers), Melissa officinalis (leaves), Mentha piperita (leaves) and Pimpinella anisum (seed). Methanol extracts of Matricaria recutita (flowers) and Ginkgo biloba (leaves) had a MIC > 100 mu g/mL. Copyright (c) 2005 John Wiley & Sons, Ltd.
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