期刊
JOURNAL OF CLINICAL IMMUNOLOGY
卷 25, 期 6, 页码 541-550出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10875-005-8217-6
关键词
NF-kappa B; IKK; cell death; cancer therapy
类别
资金
- NCI NIH HHS [CA 76188] Funding Source: Medline
- NIAID NIH HHS [AI 43477] Funding Source: Medline
- NIEHS NIH HHS [ES 04151] Funding Source: Medline
The most extensively studied function of NF-kappa B is its ability to promote cell survival through induction of target genes, whose products inhibit various aspects of the apoptotic machinery in both normal and malignant cells. Recent studies, however, indicate that NF-kappa B activation can also suppress programmed necrosis through induction of genes encoding anti-oxidant proteins. Since tumor cells often use NF-kappa B pathway as a shield to escape the killing of conventional anti-cancer therapies, intervention of IKK/NF-kappa B signaling would be a promising option to improve the efficacy of cancer treatment.
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