期刊
BIOMARKERS
卷 10, 期 -, 页码 S10-S23出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/13547500500216546
关键词
Lipid peroxidation; eicosanoid; isoprostane; lipid; oxidant stress; oxidative stress
资金
- NCI NIH HHS [CA77839] Funding Source: Medline
- NCRR NIH HHS [RR00095] Funding Source: Medline
- NIDDK NIH HHS [DK48831] Funding Source: Medline
- NIGMS NIH HHS [GM15431] Funding Source: Medline
The isoprostanes are a unique series of prostaglandin-like compounds formed in vivo via a nonenzymatic mechanism involving the free radical-initiated peroxidation of arachidonic acid. This article summarizes selected aspects regarding current knowledge of these compounds and their value as markers of oxidative injury. Novel aspects related to the biochemistry of isoprostane formation are discussed and methods by which these compounds can be analysed and quantified are summarized. A considerable portion of this article examines the utility of F-2-isoprostanes as markers of oxidant injury in vivo. Numerous studies carried out over the past decade have shown that these compounds are extremely accurate measures of lipid peroxidation and have illuminated the role of oxidant injury in a number of human diseases including atherosclerosis, Alzheimer's disease and pulmonary disorders.
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