期刊
METABOLISM-CLINICAL AND EXPERIMENTAL
卷 54, 期 11, 页码 1472-1479出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.metabol.2005.05.013
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The aim of this study was to examine the effect of aerobic exercise training on insulin sensitivity in overweight and obese girls. Nineteen overweight and obese girls (mean SD: age, 13.1 1.8 years; body mass index, 26.8 3.9 kg/m(2)) volunteered for this study. Body composition (dual-energy x-ray absorptiometry), insulin sensitivity (oral glucose tolerance test and homeostasis model assessment estimate of insulin resistance; n = 15), adiponectin, C-reactive protein (CRP), interleukin (IL) 6, insulin-like growth factor-1, soluble intercellular adhesion molecule-I and soluble vascular cell adhesion molecule-1 serum levels, and blood lipids and lipoproteins were assessed before and after 12 weeks of aerobic training. Cardiorespiratory fitness increased by 18.8% (P <.05) as a result of training. The area under the insulin concentration curve (insulin area under the curve) decreased by 23.3% (12 781.7 +/- 7454.2 vs 9799.0 +/- 4918.6 mu U center dot min/mL before and after intervention, respectively; P =.03). Insulin sensitivity was improved without changes in body weight (preintervention, 67.9 +/- 14.5 kg; postintervention, 68.3 +/- 14.0 kg) or percent body fat (preintervention, 41.4% +/- 4.8%; postintervention, 40.7% +/- 5.2%). The lower limb fat-free mass increased by 6.2% (P <.01) as a result of training, and changes in lower limb fat-free mass were correlated with changes in the insulin area under the curve (r = -.68; P <.01). Serum adiponectin, IL-6, and CRP concentrations did not change (preintervention vs postintervention: adiponectin, 9.57 +/- 3.01 vs 9.08 +/- 2.32 mu g/mL; IL-6, 1.67 +/- 1.29 vs 1.65 +/- 1.25 pg/mL, CRP, 3.21 +/- 2.48 vs 2.73 +/- 1.88 mg/L) whereas insulin-like growthfactor-1 was lower after training (preintervention, 453.8 159.3 ng/mL; postintervention, 403.2 +/- 155.1 ng/mL;P <.05). In conclusion, 12 weeks of aerobic training improved insulin sensitivity in overweight and obese girls without change in body weight, percent body fat, and circulating concentrations of adiponectin, IL-6, CRP, and other inflammatory markers. These findings suggest that increased physical activity may ameliorate the metabolic abnormalities associated with obesity in children with a mechanism other than the parameters cited earlier. (c) 2005 Elsevier Inc. All rights reserved.
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