期刊
ANTI-CANCER DRUGS
卷 23, 期 6, 页码 590-596出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CAD.0b013e32835019f9
关键词
ampelopsin sodium; antitumor activity; bladder cancer; orthotopic xenograft model; pharmacokinetics
资金
- Fundamental Research Funds for the Central universities in China [lzujbky-2009-95]
The aim of this study was to establish xenograft models of tumor in mice bladder and evaluate the antitumor efficacy of ampelopsin sodium (Amp-Na). A total of 2 x 10(6) human bladder carcinoma EJ cells and murine sarcoma 180 cells were instilled into the bladder of BALB/c nu/nu mice and Swiss mice after preconditioning to establish the tumor model. Mice bearing orthotopic tumors were treated with Amp-Na by intravenous, intraperitoneal, or intravesical instillation. In addition, the pharmacokinetics property of Amp-Na was investigated in normal BALB/c mice. Our results showed that Amp-Na was excreted mainly through the urine, where it existed at a high concentration. Amp-Na significantly inhibited the proliferation of EJ and sarcoma 180 cells both in vivo and in vitro and this can be at least partially attributed to the cell cycle arrest induced by Amp-Na. This study suggests that the use of Amp-Na is an attractive chemotherapeutic modality for bladder cancer patients. Anti-Cancer Drugs 23:590-596 (C) 2012 Wolters Kluwer Health broken vertical bar Lippincott Williams & Wilkins.
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