期刊
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
卷 144, 期 1, 页码 86-93出版社
ELSEVIER
DOI: 10.1016/j.molbiopara.2005.08.005
关键词
Plasmodium vivax; balancing selection; Pvmsp3 alpha; genetic diversity
资金
- Wellcome Trust Funding Source: Medline
The genetic diversity of a defined Plasmodium vivax population from the Venezuelan Amazon was evaluated by direct sequencing of the gene encoding the P vivax merozoite surface protein-3 alpha, Pvmsp3 alpha. Three allele sizes (1.9, 1.4 and 1.1 kb) were amplified from 58 isolates with frequencies of 59.3%, 21.9% and 18.8%, respectively. 27 Pvmsp3 alpha nucleotide sequences were determined, with nine distinct haplotypes observed. The genetic diversity (h) at this single locus was 0.774. The P. vivax population in this region exhibits significant diversity in contrast to the genetically restricted diversity of the sympatric P. falciparum population. Despite sharing vector and human hosts, different control strategies may be required for these two species in this region. Substitution patterns in the conserved C-terminus of Pvmsp3a showed a significant departure from neutrality, suggesting these polymorphisms are being maintained by frequency-dependent selection as the result of an effective immune response from the host. Our findings support the use of Pvmsp3 alpha genotyping as a tool for monitoring interventions aimed at control of P. vivax. (c) 2005 Elsevier B.V.. All rights reserved.
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