期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 49, 期 11, 页码 4775-4777出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.49.11.4775-4777.2005
关键词
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The Mycobacterium tuberculosis mmpL7 gene, encoding a hypothetical resistance nodulation division transporter, confers a high resistance level to isoniazid when overexpressed in Mycobacterium smegmatis. The resistance level decreased in the presence of the efflux pump inhibitors reserpine and CCCP (carbonyl cyanide m-chlorophenylhydrazone). Energy-dependent efflux of isoniazid from M. smegmatis cells expressing the mmpL7 gene was observed.
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