期刊
VACCINE
卷 23, 期 45, 页码 5212-5224出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2005.07.086
关键词
Indian rhesus macaque; MHC; epitope
资金
- AHRQ HHS [HHSN26620040006C] Funding Source: Medline
- NCRR NIH HHS [R24 RR15371, 5P51 RR000167] Funding Source: Medline
Non-human primates, in general, and Indian rhesus macaques, specifically, play an important role in the development and testing of vaccines and diagnostics destined for human use. To date, several frequently expressed macaque MHC molecules have been identified and their binding specificities characterized in detail. Here, we report the development of computational algorithms to predict peptide binding and potential T cell epitopes for the common MHC class I alleles Mamu-A*01, -A*02, -A*11, -B*01 and -B*17, which cover approximately two thirds of the captive Indian rhesus macaque populations. We validated this method utilizing an SIV derived data set encompassing 59 antigenic peptides. Of all peptides contained in the SIV proteome, the 2.4% scoring highest in the prediction contained 80% of the antigenic peptides. The method was implemented in a freely accessible and user friendly website at www.mamu.liai.org. Thus, we anticipate that our approach can be utilized to rapidly and efficiently identify CD8+ T cell epitopes recognized by rhesus macaques and derived from any pathogen of interest. (c) 2005 Elsevier Ltd. All rights reserved.
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