Endometrial cancer in women 45 years of age or younger: A clinicopathological analysis

Objective: The purpose of this Study was to evaluate the experience With endometrial carcinoma in women <= 45 years of age at Ochsner Clinic Foundation, New Orleans, La. Study design: We evaluated the clinical history, treatment, and follow-up of 38 women <= 45 years of age diagnosed with endometrial cancer. Results: Thirty-eight patients received primary treatment for endometrial cancer: stage 1 32 (84.2%); stage II, 1 (2.6%); stage III, 4 (10.5%); stage IV, 1 (2.6%). Tumors were well differentiated in 20 (52.6%), moderately differentiated in 10 (26.39/,,) and poorly differentiated in 8 (21.1%). At end of study period 32 women (84.2%) were alive with no evidence of disease, 5 had died of recurrent disease, and I died of metastatic breast cancer. Conclusion: Patients <= 45 years of age had lower incidence of advanced stage disease, higher degree of tumor differentiation, and better prognosis compared to patients older than 45 years. (C) 2005 Mosby, Inc. All rights reserved.