期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 131, 期 3, 页码 313-319出版社
WILEY
DOI: 10.1111/j.1365-2141.2005.05775.x
关键词
B-cell chronic lymphocytic leukaemia; CD180; toll-like receptor; IGVH mutation
类别
We have studied the surface expression of the Toll-like receptor family member CD180 on cells from 78 patients with B-chronic lymphocytic leukaemia (B-CLL). B-CLL cells had variable levels of CD180 expression, but this was always less than that expressed by normal blood B cells and was stable for 24 months. Significantly higher levels of CD180 were expressed by B-CLL cells with mutated IGVH genes compared with those using unmutated IGVH genes. This was in contrast to the higher levels of expression of surface immunoglobulin M by B-CLL cells using unmutated, rather than mutated IGVH genes. CD180 was functional on B-CLL cells from some of the patients, as shown by the increased expression of CD86 following incubation in vitro with anti-CD180. The differential expression of CD180 amongst B-CLL patients is one more marker that may define more precisely the different biological properties of this heterogeneous disease.
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