期刊
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
卷 14, 期 9, 页码 1213-1219出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1871520614666140825112924
关键词
cancer; CDKs; dual function; GSK-3; indirubin; neurodegeneration
资金
- Science and Technology Development Fund of Macau SAR [078/2011/A3]
- Research Committee, University of Macau
Indirubin is an active ingredient mainly used to treat leukemia in China and is reported to be a leading inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3) by competing with ATP binding sites. New findings have indicated that its comprehensive structure may contribute to its polypharmacological activities particularly in cancer and neurodegenerative disease therapy, as both of these diseases are usually accompanied by a common molecular link related to abnormal phosphorylation of CDKs and GSK-3. In the elderly, cancer and neurodegenerative disease are tightly associated common diseases and sometimes unavoidably coexist. In this review, the underlying mechanisms of the dual actions of indirubin and its structurally-related compounds in cancer and neurodegenerative disease therapy are presented.
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