期刊
JOURNAL OF NEUROLOGY
卷 252, 期 11, 页码 1345-1352出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00415-005-0864-2
关键词
Parkinson's disease; dementia; MRI; voxel-based morphometry; longitudinal study
Objective To investigate the pattern of brain atrophy across time in a sample of Parkinson's disease (PD) patients with and without dementia using voxel-based morphometry (VBM) analysis. Methods The initial sample comprised thirteen non-demented PD patients and sixteen demented patients. Longitudinal cognitive assessment and structural MRI were performed. The mean follow-up period was 25 months (SD = 5.2). From this initial group, eight PD patients with dementia (5 men and 3 women) and eleven PD patients without dementia (7 men and 4 women) were reevaluated. MRI 3D structural images were acquired and analyzed by means of the optimized VBM procedure with Statistical Parametric Mapping (SPM2). Results VBM analysis showed a progressive grey matter volume decrease in patients with PD without dementia in limbic, paralimbic and neocortical associative temporo-occipital regions. In patients with dementia the loss mainly involved neocortical regions. Conclusion VBM revealed a significant loss of grey matter volume in PD patients with and without dementia with disease progression. The decrease in limbic and paralimbic regions is widespread in non-demented patients. Neocortical volume reduction is the most relevant finding in patients with dementia. This suggests that the neocortex is a substrate for dementia in Parkinson disease.
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