期刊
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
卷 13, 期 8, 页码 1149-1161出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1871520611313080003
关键词
Pomegranate extracts; cancer prevention
资金
- United States Public Health Service [R01 CA 78809, R01 CA 101039, P50 DK065303-01, RO1 CA 120451]
There is increased appreciation by the scientific community that dietary phytochemicals can be potential weapons in the fight against cancer. Emerging data has provided new insights into the molecular and cellular framework needed to establish novel mechanism-based strategies for cancer prevention by selective bioactive food components. The unique chemical composition of the pomegranate fruit, rich in antioxidant tannins and flavonoids has drawn the attention of many investigators. Polyphenol rich fractions derived from the pomegranate fruit have been studied for their potential chemopreventive and/or cancer therapeutic effects in several animal models. Although data from in vitro and in vivo studies look convincing, well designed clinical trials in humans are needed to ascertain whether pomegranate can become part of our armamentarium against cancer. This review summarizes the available literature on the effects of pomegranate against various cancers.
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