期刊
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
卷 8, 期 7, 页码 723-731出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/187152008785914833
关键词
Cell cycle; cyclins; CDKs; CDK inhibitors; cancer therapeutic targets
资金
- Swedish Cancer Society
- Government Health Grant (ALF)
- Lund University Medical Faculty Grant
- Swedish Children Foundation
- Gunnar Nilsson Cancer Foundation
- Crafoords Foundation
- MAS Cancer Foundation
- MAS Foundation
Cyclins and CDKs play critical roles in DNA synthesis and cell division. Alterations in their function may lead to the disruption of normal cell growth and apoptosis, and subsequently, result in carcinogenesis. Elevated levels of cyclins and CDKs are frequently observed in a wide range of different types of human cancers. Understanding of molecular mechanisms underlying the cell cycle effects in response to the chemotherapeutic agents is of great importance for improving the efficacy of targeted therapeutics and overcoming resistance to chemotherapeutic agents. Despite the clinical applications of cell cycle specific chemotherapeutic agents, there is still an urgent need to develop novel drugs that can target multiple sites and pathways of the cell cycle while avoiding drug induced cytotoxicity. In this review article, we will summarize the development of novel agents that specifically target cell cycle pathways in human cancer. We will discuss drugs that can directly interfere with the mitotic process of tumor cells. Moreover, we tend to address the significance of using small molecule CDK inhibitors that are derived from natural products.
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