期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 60, 期 11, 页码 1484-1487出版社
GERONTOLOGICAL SOCIETY AMER
DOI: 10.1093/gerona/60.11.1484
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资金
- Intramural NIH HHS [Z01 AG000294] Funding Source: Medline
- NCRR NIH HHS [M01 RR002635] Funding Source: Medline
- NIA NIH HHS [AG00294, AG05134, P01 AG004390, AG08812, K12 AG000294, P50 AG005134, AG04390, P60 AG008812] Funding Source: Medline
Background. We used transcranial Doppler ultrasonography to examine the cerebral blood flow response to orthostatic stress in the middle and posterior cerebral circulations and to determine the effects of healthy aging on regional cerebral blood flow regulation. Methods. Continuous simultaneous middle (MCA) and posterior (PCA) cerebral artery blood flow velocities (BFV) and mean arterial pressure (MAP) were measured in response to standing from a sitting position in 13 younger (30 +/- 7 years) and 13 older (73 +/- 4 years) healthy participants. Results. The older participants had a significantly larger decline in MAP (-31% +/- 3 in the older and -21% +/- 2 in the younger) and a smaller increase in heart rate (HR) (15 bpm +/- 1 in the older, 24 bpm +/- 2 in the younger) during the Posture change. Despite a larger decline in MAP, the older participants had a decline very similar to that of the younger participants in BFVs in both vascular territories. This was associated with a significantly larger vasodilatory response in the MCA and PCA vascular territories of the older participants. There were no regional differences of the cerebrovascular resistance and BFV responses to orthostasis in the younger participants. However, in the older participants, there was a significantly larger BFV decline and a smaller vasodilatory response in the PCA as compared to the MCA territory. Conclusions. Healthy aging is associated with preserved cerebrovascular adaptation to orthostatic hypotension. However, in older persons, the PCA territory blood flow may be more vulnerable to reduced perfusion during orthostatic stress.
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