期刊
JOURNAL OF NEURAL TRANSMISSION
卷 112, 期 11, 页码 1547-1564出版社
SPRINGER WIEN
DOI: 10.1007/s00702-005-0326-0
关键词
brain trauma; axonal injury; Alzheimer's disease; transgenic mice; amyloid precursor protein
Traumatic Brain Injury is the leading cause of death and disability among young individuals in our society. Moreover, according to some epidemiological studies, head trauma is one of the most potent environmental risk factors for subsequent development of Alzheimer's disease. Interestingly, pathological features that are present also in Alzheimer's disease (in particular deposition of beta-amyloid protein) were observed in traumatised brains already a few hours after the initial insult. The primary objective of this review is to present methodology and results of numerous recent human and animal studies dealing with this issue. Special emphasis was placed on head trauma experiments in transgenic mouse models of Alzheimer's disease. We further evaluate the connection between traumatic brain insults and subsequent development of dementia and try to differentiate between primary and secondary pathological mechanisms.
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