期刊
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
卷 40, 期 3, 页码 276-279出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.qai.0000176653.89769.4d
关键词
SDF-1 3 ' A; CCR5-Delta 32; genetic polymorphism; HIV-1 infection; long-term nonprogressors
We studied the frequency of the SDF-1 3'A allelic variant (801G -> A) in a cohort of white Spaniards made up of (1) HIV-1-infected long-term nonprogressors (LTNPs) older than 16 years of age (n = 57), (2) HIV-1-infected usual progressors (UPs; n = 107), and (3) a group of healthy controls (n = 100). The mutant SDF-1 3'A allele was observed in 28% of LTNPs, 19% of UPs, and 26% of healthy controls (P = not significant). Homozygosity for the 3'A mutation was detected in 7%, 4%, and 3% of LTNPs, UPs, and healthy controls, respectively (P = not significant). Polymorphism at the SDF-1 locus is not associated with LTNP disease of longer than 16 years in Spanish HIV-1-infected patients. This effect is independent of the CCR5 Delta 32 allele.
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