期刊
PATHOLOGE
卷 26, 期 6, 页码 473-+出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00292-005-0789-7
关键词
prostate specific antigen (PSA); prostate cancer (PCa); surveillance
类别
Prostate specific antigen is the most important tumor marker of prostate cancer. PSA, in conjunction with digital rectal examination, is the first-line clinical tool for detection of prostate cancer. To improve its specifity PSA-density, PSA-ratio (fPSA/tPSA), PSA-velocity, and complexed PSA have been introduced into clinical praxis. The treatment of lower stage disease in younger men has resulted in a longer period of post-treatment cancer surveillance. Biochemical recurrence is an early indicator for clinical disease recurrence. PSA doubling time allows to distinguish between local and systemic progression and is also a valid predictor for distant metastasis and death of disease.
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