期刊
ANTIVIRAL RESEARCH
卷 68, 期 2, 页码 96-108出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.antiviral.2005.07.006
关键词
HIV coreceptors; HAART; CCR5; coreceptor inhibitor
资金
- NIAID NIH HHS [AI062514] Funding Source: Medline
- NIMH NIH HHS [R01MH64408] Funding Source: Medline
Highly active anti-retroviral therapy (HAART) has been very effective in reducing viral loads in human immunodeficiency virus (HIV)-1 patients. However, current therapies carry detrimental side effects, require complex drug regimes and are threatened by the emergence of drug-resistant variants. There is an urgent need for new anti-HIV drugs that target different stages of the replication cycle. Several synthetic small organic molecules that inhibit HIV infection by binding to the CCR5 coreceptor without causing cell activation have already been reported. Here, we have exploited a series of CCR5 antagonists to investigate their effects on diverse HIV and the simian counterpart (SIV) isolates for infection of a variety of cell types via different concentrations of cell surface CCR5. These inhibitors show no cross-reactivity against alternative HIV coreceptors including CCR3, CCR8, GPR1, APJ, CXCR4 and CXCR6. They are able to inhibit a diverse range of R5 and R5X4 HIV-1 isolates as well as HIV-2 and SIV strains. Inhibition was observed in cell lines as well as primary PBMCs and macrophages. The extent of inhibition was dependent on cell type and on cell surface CCR5 concentration. Our results underscore the potential of CCR5 inhibitors for clinical development. (c) 2005 Elsevier B.V. All rights reserved.
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