Seven new sesquiterpene lactones from Eupatorium chinense

Seven new sesquiterpenoids, namely eupatochinilides I-VII (1-7), together with eight known compounds, euponin (8), mollisorin A (9), niveusin B (10), 8 beta-(4'-acetoxy-tiglyloxy)-3 beta-hydroxy-6H(beta),7H(alpha)-germacra-1(10)E,4E,11(13)-trien-6,12-olide (11), eupalinilide B (12), 8 beta-(4'-hydroxytigloyloxy)-5-desoxy-8-desacyleuparotin (13), 3-deacetyeupalinin A (14), and 15-hydroxyleptocarpin (15), were isolated from the ethanolic extract of the whole plant of Eupatorium chinense L. Their structures and stereochemistry were established by spectroscopic methods and GIAO based C-13 NMR chemical shift calculations.