期刊
PEPTIDES
卷 26, 期 11, 页码 2182-2187出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2005.03.049
关键词
aminopeptidase N (APN/CD13); tumor-homing peptide; CNGRC; fluorescent probe; molecular imaging
A family of fluorescein-peptide conjugates (CNP1-3) for aminopeptidase N (APN/CD13) targeting fluorescent probes were designed and synthesized. Among the three conjugates, CNP1 bearing tumor-homing cyclic peptide CNGRC, could selectively label APN/CD13 over-expressing on the surface of tumor cells of HT-1080, as identified by means of fluorescent microscopic cell imaging. CNP1 was shown to be a promising fluorescent probe applicable to tumor-targeting molecular imaging. (c) 2005 Elsevier Inc. All rights reserved.
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