期刊
JOURNAL OF NEUROPHYSIOLOGY
卷 94, 期 5, 页码 3637-3642出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.00686.2005
关键词
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We introduce a two-dimensional integrateand- fire model that combines an exponential spike mechanism with an adaptation equation, based on recent theoretical findings. We describe a systematic method to estimate its parameters with simple electrophysiological protocols (current-clamp injection of pulses and ramps) and apply it to a detailed conductance-based model of a regular spiking neuron. Our simple model predicts correctly the timing of 96% of the spikes ( +/- 2 ms) of the detailed model in response to injection of noisy synaptic conductances. The model is especially reliable in high-conductance states, typical of cortical activity in vivo, in which intrinsic conductances were found to have a reduced role in shaping spike trains. These results are promising because this simple model has enough expressive power to reproduce qualitatively several electrophysiological classes described in vitro.
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