期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 48, 期 22, 页码 6787-6789出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm0507173
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资金
- NIEHS NIH HHS [T32 ES 07028-28] Funding Source: Medline
Because alpha-tocopherol (alpha-TOH) mediates the peroxidation of cholesterol-esterified lipids in human low-density lipoprotein (LDL) in vitro and has displayed disappointing results against the onset and development of atherosclerosis, it may not be appropriate for use as a therapeutic in the prevention and/or treatment of the disease. Herein are described the experimental results demonstrating that 3-pyridinols spare alpha-TOH, do not efficiently mediate lipid peroxidation, and protect lipoprotein tryptophan residues in human LDL.
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