期刊
ANNUAL REVIEW OF PUBLIC HEALTH, VOL 32
卷 32, 期 -, 页码 237-262出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-publhealth-031210-101230
关键词
maternal nutrition; prenatal exposure delayed effects; Dutch famine; Great Leap Forward famine; Siege of Leningrad
资金
- NHLBI NIH HHS [R01-HL67914, R01 HL067914] Funding Source: Medline
- NIA NIH HHS [R01 AG028593, R01-AG028593] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL067914] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG028593] Funding Source: NIH RePORTER
We review human studies on the relation between acute exposures to prenatal famine and adult physical and mental health. These studies are observational and include exposures to a famine environment by natural or man-made causes or, more commonly, from the interplay between natural and human factors. These natural experiments provide an opportunity to examine long-term outcomes after famine exposures by comparing exposed and nonexposed individuals. The studies show consistent associations between prenatal famine and adult body size, diabetes, and schizophrenia. For other measures of adult health, findings are less robust. A relation between prenatal famine and some reported epigenetic changes may provide a potential mechanism to explain specific associations. Much progress can be made if current separate studies are further analyzed with comparable definitions of exposures and outcomes and using common analytic strategies.
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