相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Biomarkers in Population Studies: Environmental Mutagenesis and Risk for Cancer
W.W. Au et al.
REVIEWS ON ENVIRONMENTAL HEALTH (2011)
In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project
Richard S. Judson et al.
ENVIRONMENTAL HEALTH PERSPECTIVES (2010)
Cannabinoid 1 Receptor and Interleukin-6 Receptor Together Induce Integration of Protein Kinase and Transcription Factor Signaling to Trigger Neurite Outgrowth
Yana Zorina et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
ADVANCING EXPOSURE CHARACTERIZATION FOR CHEMICAL EVALUATION AND RISK ASSESSMENT
Elaine A. Cohen Hubal et al.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2010)
AN ANIMAL PROTECTION PERSPECTIVE ON 21ST CENTURY TOXICOLOGY
Martin L. Stephens
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2010)
TOXICITY TESTING IN THE 21ST CENTURY: HOW WILL IT AFFECT RISK ASSESSMENT?
Lorenz R. Rhomberg
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2010)
THE FUTURE OF TOXICITY TESTING
Melvin E. Andersen et al.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2010)
THE REACH PERSPECTIVE: TOWARD A NEW CONCEPT OF TOXICITY TESTING
Greet Schoeters
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2010)
IMPLEMENTING THE NATIONAL ACADEMY'S VISION AND STRATEGY FOR TOXICITY TESTING: OPPORTUNITIES AND CHALLENGES UNDER THE US TOXIC SUBSTANCES CONTROL ACT
Paul A. Locke et al.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2010)
BIOKINETIC MODELING AND IN VITRO-IN VIVO EXTRAPOLATIONS
Bas J. Blaauboer
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2010)
PUBLIC DATABASES SUPPORTING COMPUTATIONAL TOXICOLOGY
Richard Judson
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2010)
XENOBIOTIC-METABOLIZING ENZYME AND TRANSPORTER GENE EXPRESSION IN PRIMARY CULTURES OF HUMAN HEPATOCYTES MODULATED BY TOXCAST CHEMICALS
Daniel M. Rotroff et al.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2010)
LESSONS LEARNED FROM ALTERNATIVE METHODS AND THEIR VALIDATION FOR A NEW TOXICOLOGY IN THE 21ST CENTURY
Thomas Hartung
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2010)
COMPUTATIONAL SYSTEMS BIOLOGY AND DOSE-RESPONSE MODELING IN RELATION TO NEW DIRECTIONS IN TOXICITY TESTING
Qiang Zhang et al.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2010)
COMPUTATIONAL TOXICOLOGY AS IMPLEMENTED BY THE US EPA: PROVIDING HIGH THROUGHPUT DECISION SUPPORT TOOLS FOR SCREENING AND ASSESSING CHEMICAL EXPOSURE, HAZARD AND RISK
Robert Kavlock et al.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2010)
VIRTUAL TISSUES IN TOXICOLOGY
Imran Shah et al.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2010)
MEETING THE COMMON NEEDS OF A MORE EFFECTIVE AND EFFICIENT TESTING AND ASSESSMENT PARADIGM FOR CHEMICAL RISK MANAGEMENT
Vicki Dellarco et al.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2010)
The 2010 Nucleic Acids Research Database Issue and online Database Collection: a community of data resources
Guy R. Cochrane et al.
NUCLEIC ACIDS RESEARCH (2010)
Toxicity Testing in the 21st Century: Using the New Toxicity Testing Paradigm to Create a Taxonomy of Adverse Effects
Kim Boekelheide et al.
TOXICOLOGICAL SCIENCES (2010)
The Vision of Toxicity Testing in the 21st Century: Moving from Discussion to Action
Melvin E. Andersen et al.
TOXICOLOGICAL SCIENCES (2010)
A systems biology perspective on Nrf2-mediated antioxidant response
Qiang Zhang et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2010)
Quantitative Structure-Activity Relationship (QSAR) Modeling of Human Blood: Air Partitioning with Proper Statistical Methods and Validation
Subhash C. Basak et al.
CHEMISTRY & BIODIVERSITY (2009)
In silico Prediction of Human Oral Absorption Based on QSAR Analyses of PAMPA Permeability
Miki Akamatsu et al.
CHEMISTRY & BIODIVERSITY (2009)
High Throughput Optimization of Stem Cell Microenvironments
Fan Yang et al.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2009)
Evaluation of a Suitable DNA Damage Biomarker for Human Biomonitoring of Exposed Workers
Delia Cavallo et al.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2009)
A QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP FOR PREDICTING METABOLIC BIOTRANSFORMATION RATES FOR ORGANIC CHEMICALS IN FISH
Jon A. Arnot et al.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2009)
Genomic and proteomic approaches for predicting toxicity and adverse drug reactions
Feng Ge et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2009)
Modelling tissues in 3D: the next future of pharmaco-toxicology and food research?
Giovanna Mazzoleni et al.
GENES AND NUTRITION (2009)
Functional Expression of β2 Adrenergic Receptors Responsible for Protection Against Oxidative Stress Through Promotion of Glutathione Synthesis After Nrf2 Upregulation in Undifferentiated Mesenchymal C3H10T1/2 Stem Cells
Yoshifumi Takahata et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2009)
QSAR application for the prediction of compound permeability with in silico descriptors in practical use
Kazuya Nakao et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2009)
8-hydroxy-2′ -deoxyguanosine (8-OHdG): A Critical Biomarker of Oxidative Stress and Carcinogenesis
ATHANASIOS VALAVANIDIS et al.
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS (2009)
The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds
Makoto Kobayashi et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Risk Assessment in the 21st Century: Changes Wrought by Changing Science
Lorenz R. Rhomberg
RISK ANALYSIS (2009)
Commentary on Toxicity Testing in the 21st Century: Implications for Human Health Risk Assessment by Krewski et al.
Rory B. Conolly
RISK ANALYSIS (2009)
Needed: A Strategy for Implementing the Vision
E. Donald Elliott
RISK ANALYSIS (2009)
Advances in Toxicity Testing Herald Improvements and Challenges for Risk Assessment
Joyce S. Tsuji et al.
RISK ANALYSIS (2009)
High-Throughput Testing-The NRC Vision, The Challenge of Modeling Dynamic Changes in Biological Systems, and the Reality of Low-Throughput Environmental Health Decision Making
Dale Hattis
RISK ANALYSIS (2009)
Toxicity Testing in the 21st Century: Implications for Human Health Risk Assessment
Robert J. Kavlock et al.
RISK ANALYSIS (2009)
Toxicity Testing in the 21st Century: Implications for Human Health Risk Assessment
Daniel Krewski et al.
RISK ANALYSIS (2009)
How not to develop a quantitative structure-activity or structure-property relationship (QSAR/QSPR)
J. C. Dearden et al.
SAR AND QSAR IN ENVIRONMENTAL RESEARCH (2009)
Putting Chemicals on a Path To Better Risk Assessment
Erik Stokstad
SCIENCE (2009)
Impact of Shifting Patterns of Pacific Ocean Warming on North Atlantic Tropical Cyclones
Hye-Mi Kim et al.
SCIENCE (2009)
Minimum Information About a Microarray Experiment (MIAME) - Successes, Failures, Challenges
Alvis Brazma
THESCIENTIFICWORLDJOURNAL (2009)
Forum Series: The Vision for Toxicity Testing in the 21st Century: Promises and Conundrums
Michael P. Holsapple et al.
TOXICOLOGICAL SCIENCES (2009)
Toxicity Testing in the 21st Century: Bringing the Vision to Life
Melvin E. Andersen et al.
TOXICOLOGICAL SCIENCES (2009)
Toxicity Testing in the 21st Century: A View from the Chemical Industry
James S. Bus et al.
TOXICOLOGICAL SCIENCES (2009)
Hypoxia Response: A Model Toxicity Pathway for High-Throughput Screening
Steven O. Simmons
TOXICOLOGICAL SCIENCES (2009)
Pragmatic Challenges for the Vision of Toxicity Testing in the 21(st) Century in a Regulatory Context: Another Ames Test? ...or a New Edition of the Red Book?
Bette Meek et al.
TOXICOLOGICAL SCIENCES (2009)
A Toxicology for the 21st Century-025EFMapping the Road Ahead
Thomas Hartung
TOXICOLOGICAL SCIENCES (2009)
Endless Possibilities: Stem Cells and the Vision for Toxicology Testing in the 21st Century
Robert E. Chapin et al.
TOXICOLOGICAL SCIENCES (2009)
A 21st Century Paradigm for Evaluating the Health Hazards of Nanoscale Materials?
Nigel J. Walker et al.
TOXICOLOGICAL SCIENCES (2009)
Toxicity Testing in the 21st Century: A View from the Pharmaceutical Industry
James S. MacDonald et al.
TOXICOLOGICAL SCIENCES (2009)
Biologically Relevant Exposure Science for 21st Century Toxicity Testing
Elaine A. Cohen Hubal
TOXICOLOGICAL SCIENCES (2009)
In silico toxicology for the pharmaceutical sciences
Luis G. Valerio
TOXICOLOGY AND APPLIED PHARMACOLOGY (2009)
Bringing toxicology into the 21st century: A global call to action
T. Seidle et al.
TOXICOLOGY IN VITRO (2009)
Inorganic arsenic modulates the expression of selenoproteins in mouse embryonic stem cell
Zhi Huang et al.
TOXICOLOGY LETTERS (2009)
Biomarkers of nucleic acid oxidation, polymorphism in, and expression of, hOGG1 gene in styrene-exposed workers
Paola Manini et al.
TOXICOLOGY LETTERS (2009)
A Kinetic Model of Trp-Cage Folding from Multiple Biased Molecular Dynamics Simulations
Fabrizio Marinelli et al.
PLOS COMPUTATIONAL BIOLOGY (2009)
Stem Cells in Drug Discovery, Tissue Engineering, and Regenerative Medicine: Emerging Opportunities and Challenges
Victor Sanjit Nirmalanandhan et al.
JOURNAL OF BIOMOLECULAR SCREENING (2009)
A DATABASE OF FISH BIOTRANSFORMATION RATES FOR ORGANIC CHEMICALS
Jon A. Arnot et al.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2008)
Systems biology and functional genomics approaches for the identification of cellular responses to drug toxicity
Alison Hege Harrill et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2008)
Toxicology - Transforming environmental health protection
Francis S. Collins et al.
SCIENCE (2008)
Design logic of a cannabinoid receptor signaling network that triggers neurite outgrowth
Kenneth D. Bromberg et al.
SCIENCE (2008)
Understanding mechanisms of toxicity: Insights from drug discovery research
Keith A. Houck et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2008)
Understanding genetic toxicity through data mining: The process of building knowledge by integrating multiple genetic toxicity databases
C. Yang et al.
TOXICOLOGY MECHANISMS AND METHODS (2008)
Toxicity data informatics: Supporting a new paradigm for toxicity prediction
Ann M. Richard et al.
TOXICOLOGY MECHANISMS AND METHODS (2008)
Network Inference Algorithms Elucidate Nrf2 Regulation of Mouse Lung Oxidative Stress
Ronald C. Taylor et al.
PLOS COMPUTATIONAL BIOLOGY (2008)
Compound cytotoxicity profiling using quantitative high-throughput screening
Menghang Xia et al.
ENVIRONMENTAL HEALTH PERSPECTIVES (2008)
Induced pluripotent stem cell lines derived from human somatic cells
Junying Yu et al.
SCIENCE (2007)
Induction of pluripotent stem cells from adult human fibroblasts by defined factors
Kazutoshi Takahashi et al.
CELL (2007)
An integrated framework for risk management and population health
Daniel Krewski et al.
HUMAN AND ECOLOGICAL RISK ASSESSMENT (2007)
Estrogenic effects in the immature rat uterus after dietary exposure to ethinylestradiol and zearalenone using a systems biology approach
Marjoke Heneweer et al.
TOXICOLOGICAL SCIENCES (2007)
The minimum information about a proteomics experiment (MIAPE)
Chris F. Taylor et al.
NATURE BIOTECHNOLOGY (2007)
Toxicogenomics: a pivotal piece in the puzzle of toxicological research
Elisavet T. Gatzidou et al.
JOURNAL OF APPLIED TOXICOLOGY (2007)
Network motifs: theory and experimental approaches
Uri Alon
NATURE REVIEWS GENETICS (2007)
Quantitative high-throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries
James Inglese et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Reactive oxygen species as signaling molecules in cardiovascular differentiation of embryonic stem cells and tumor-induced angiogenesis
H Sauer et al.
ANTIOXIDANTS & REDOX SIGNALING (2005)
Stabilization of nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells
J Li et al.
TOXICOLOGICAL SCIENCES (2005)
Nuclear oncoprotein prothymosin α is a partner of Keap1:: Implications for expression of oxidative stress-protecting genes
RN Karapetian et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Dose-response modeling in reproductive toxicology in the systems biology era
ME Andersen et al.
REPRODUCTIVE TOXICOLOGY (2005)
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate for proteasomal degradation of Nrf2
A Kobayashi et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Toxicoproteomics: Proteomics applied to toxicology and pathology
BA Wetmore et al.
TOXICOLOGIC PATHOLOGY (2004)
Nrf2-Keap1 defines a physiologically important stress response mechanism
H Motohashi et al.
TRENDS IN MOLECULAR MEDICINE (2004)
Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway - Identification of novel gene clusters for cell survival
MK Kwak et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)