Δ3-Aryl/heteroaryl substituted heterocycles via sequential Pd-catalysed termolecular cascade/ring closing metathesis (RCM)

A novel sequential Pd-catalysed termolecular allenylation cascade/Ru catalysed RCM process affords a diverse range of Delta(3)-aryl/ heteroaryl substituted five-seven membered nitrogen and oxygen heterocycles. Further elaboration, via 1,3-dipolar cycloaddition, in selected cases, afforded fused heterocyclic ring systems. (c) 2005 Elsevier Ltd. All rights reserved.