期刊
ANNUAL REVIEW OF PUBLIC HEALTH
卷 30, 期 -, 页码 137-150出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.publhealth.031308.100155
关键词
nanomaterial; nanotoxicology; reactive oxygen species; oxidative stress
资金
- Environmental Protection Agency [EF 0830117]
- U.S. Public Health Service [U 19 AJ070453, ROI ES016746, ROI ES 10553, ROI ESOI 5498]
- U.S. EPA STAR [RD-83241301]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U19AI070453] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES015498, R01ES016746, R01ES010553] Funding Source: NIH RePORTER
- Div Of Biological Infrastructure [0830117] Funding Source: National Science Foundation
Although mankind stands to obtain great benefit from nanotechnology, it is important to consider the potential health impacts of nanomaterials (NMs). This consideration has launched the field of nanotoxicology, which is charged with assessing toxicological potential as well as promoting safe design and use of NMs. Although no human ailments have been ascribed to NMs thus far, early experimental studies indicate that NMs could initiate adverse biological responses that can lead to toxicological outcomes. One of the principal mechanisms is the generation of reactive oxygen species and oxidant injury. Because oxidant injury is also a major mechanism by which ambient ultrafine particles can induce adverse health effects, it is useful to consider the lessons learned from studying ambient particles. This review discusses the toxicological potential of NMs by comparing the possible injury mechanisms and adverse health effects of engineered and ambient ultrafine particles.
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