期刊
ANNUAL REVIEW OF PUBLIC HEALTH
卷 30, 期 -, 页码 107-122出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.publhealth.031308.100143
关键词
early life exposure; skin lesions; childhood cancer; methylation
资金
- National Institutes of Health [P42-ES04705, ROI-HLO81520, ROI-ES014032]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL081520] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P42ES004705, R01ES014032] Funding Source: NIH RePORTER
Even at high concentrations, arsenic-contaminated water is translucent, tasteless, and odorless. Yet almost every day, studies report a continually increasing plethora of toxic effects that have manifested in exposed populations throughout the world. In this article we focus on recent findings, in particular those associated with major contributions since 2006. Early He exposure, both in utero and in childhood, has been receiving increased attention, and remarkable increases in consequent mortality in young adults have been reported. New studies address the close-response relationship between drinking-water-arsenic concentrations and skin lesions, and new findings have emerged concerning arsenic and cardiovascular disease. We also review the increasing epidemiological evidence that the first step of methylation of inorganic arsenic to monomethylated arsenic (MMA) is actually an activation step rather than the first step in detoxification, as once thought. Hexavalent chromium differs from arsenic in that it discolors water, turning the water yellow at high concentrations. A controversial issue is whether chromium causes cancer when ingested. A recent publication supports the original findings in China of increased cancer mortality in a population where well water turned yellow with chromium.
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