期刊
CANCER LETTERS
卷 229, 期 1, 页码 1-11出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2004.12.002
关键词
DNA damage; base excision repair (BER); oxidative stress; reactive oxygen species (ROS)
类别
资金
- NIEHS NIH HHS [ES07126, ES11660, ES11391] Funding Source: Medline
Oxidative stress induced DNA damage is considered to be the most common insult affecting the genome. Moreover, it is recognized as a common pathway to mutations and is suggested to play a major role in the development of chronic diseases such as cancer. However, current analytical methods used to detect oxidative DNA damage have been hampered by both technical and biological obstacles. These include spurious oxidation during DNA isolation and processing, and the inherent removal of damaged bases by numerous operating DNA repair systems. The removal of oxidized bases is performed predominantly by the base excision repair (BER) pathway and it has been shown that induction of DNA repair genes occurs in response to oxidative stress. Here, we demonstrate the utility of measuring changes in expression of BER genes as a sensitive in vivo biomarker for oxidative DNA damage. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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