期刊
ANNUAL REVIEW OF PSYCHOLOGY, VOL 65
卷 65, 期 -, 页码 41-70出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-psych-010213-115100
关键词
behavioral genetics; heritability; diathesis-stress; differential susceptibility; vantage sensitivity; gene-environment correlation
资金
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL040962] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [U01DK056992] Funding Source: NIH RePORTER
- NHLBI NIH HHS [P01 HL040962] Funding Source: Medline
- NIDDK NIH HHS [U01 DK056992-11S1] Funding Source: Medline
With the advent of increasingly accessible technologies for typing genetic variation, studies of gene-environment (GxE) interactions have proliferated in psychological research. Among the aims of such studies are testing developmental hypotheses and models of the etiology of behavioral disorders, defining boundaries of genetic and environmental influences, and identifying individuals most susceptible to risk exposures or most amenable to preventive and therapeutic interventions. This research also coincides with the emergence of unanticipated difficulties in detecting genetic variants of direct association with behavioral traits and disorders, which may be obscured if genetic effects are expressed only in predisposing environments. In this essay we consider these and other rationales for positing GxE interactions, review conceptual models meant to inform GxE interpretations from a psychological perspective, discuss points of common critique to which GxE research is vulnerable, and address the role of the environment in GxE interactions.
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