期刊
ORGANIC LETTERS
卷 7, 期 23, 页码 5175-5178出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol0520267
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资金
- NIGMS NIH HHS [GM-62924] Funding Source: Medline
The N-7-C-25 fragment of the potent and selective cytotoxic agent psymberin has been prepared through a short (12 linear steps, 15 total steps) and stereoselective sequence. Highlights of this route include a very rapid construction of the pentasubstituted arene, a substrate-controlled diastereoselective fragment coupling using a Mukaiyama aldol reaction, and an efficient entry into a key tetrahydropyranyl cyanide.
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