期刊
ANNUAL REVIEW OF PLANT BIOLOGY, VOL 65
卷 65, 期 -, 页码 187-+出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-arplant-050213-035825
关键词
metabolic bottleneck; metabolic branch; metabolic conversion; metabolic diversity; multigene engineering
资金
- European Research Council [232933] Funding Source: Medline
- ICREA Funding Source: Custom
Metabolic engineering can be used to modulate endogenous metabolic pathways in plants or introduce new metabolic capabilities in order to increase the production of a desirable compound or reduce the accumulation of an undesirable one. In practice, there are several major challenges that need to be overcome, such as gaining enough knowledge about the endogenous pathways to understand the best intervention points, identifying and sourcing the most suitable metabolic genes, expressing those genes in such a way as to produce a functional enzyme in a heterologous background, and, finally, achieving the accumulation of target compounds without harming the host plant. This article discusses the strategies that have been developed to engineer complex metabolic pathways in plants, focusing on recent technological developments that allow the most significant bottlenecks to be overcome.
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