期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 70, 期 23, 页码 9480-9485出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo0515529
关键词
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The synthesis of three marine sponge metabolites, luffolide (4), 5, and 6, are described for the first time, establishing the absolute configuration of these compounds. The key intermediate, aldehyde 17, wash obtained from methyl isoanticopalate, 11. The addition of 3-furyllithium to 17 and subsequent photochemical oxidation give the gamma-hydroxybutenolide 5 and its epimer at C-16. Sesterterpenolide 6 is obtained by dehydration of 5. From the key aldehyde 17, luffolide (4) was obtained in six steps.
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