期刊
ONCOGENE
卷 24, 期 50, 页码 7394-7400出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1209089
关键词
PTEN; AKT; nucleus
资金
- NCI NIH HHS [CA097097] Funding Source: Medline
Several recent reports have brought conclusive evidence that the tumor suppressor PTEN, once considered a strictly cytoplasmic protein, shuttles to the nuclear compartment, where it joins a variety of components of the same pathway it regulates in the cytoplasm, among which PI3K, PDK1 and AKT. In this review, we focus on the growing supporting evidence for an important physiological role of this nuclear pathway and on the role that alteration of this novel regulatory circuit may play during cell transformation.
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