期刊
ANNUAL REVIEW OF PHYSIOLOGY, VOL 75
卷 75, 期 -, 页码 69-93出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-physiol-030212-183737
关键词
miRNA; vascular smooth muscle cells; endothelial cells; cardiac myocytes
类别
资金
- NHLBI NIH HHS [R01 HL093154, R01 HL108317] Funding Source: Medline
In 1993, lin-4 was discovered as a critical modulator of temporal development in Caenorhabditis elegans and, most notably, as the first in the class of small, single-stranded noncoding RNAs now defined as microRNAs (miRNAs). Another eight years elapsed before miRNA expression was detected in mammalian cells. Since then, explosive advancements in the field of miRNA biology have elucidated the basic mechanism of miRNA biogenesis, regulation, and gene-regulatory function. The discovery of this new class of small RNAs has augmented the complexity of gene-regulatory programs as well as the understanding of developmental and pathological processes in the cardiovascular system. Indeed, the contributions of miRNAs in cardiovascular development and function have been widely explored, revealing the extensive role of these small regulatory RNAs in cardiovascular physiology.
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